Some supplements are made in laboratories whilst other supplements get their nutrients from foods (A and D). Supplements made in laboratories are made from natural precursors meaning they may be labelled as natural. Vitamins A, D, E and K are best from natural sources as they're in oils and fats.
Some people may think with vitamin B supplements that they are getting all the needed vitamins although this isn't always true as the supplements only contain 8-12 different types. A lot of vitamin C supplements are made in laboratories and usually are pharmaceutical grade ascorbic acid. Rutin/other analogs (minerals) help to buffer the vitamin and to increase the bioavailability in vitamin C that comes from natural foods.
With other nutrients and substances, minerals in the food appear a lot in complexes and supplements (minerals) are there in engineered complexes. Calcium hydroxyapatite is the only form of a natural food extract when it comes to the most popularly taken mineral supplement which is calcium.
Vitamins B, D, E and K are not present in multivitamins meaning that it can mislead people into thinking they are getting all their vitamins from multivitamin supplements. It's also worth noting that although vitamin supplementation can help, but they only help to support a diet and not make one.
